inForm™
CRi's inForm™ has been developed to address the biggest challenge facing microscopists once quantitative imagery has been acquired: extracting data. The challenge grows when dealing with multiplexed assays, since signals can be weak and highly mixed. inForm provides a powerful and fast solution with an intuitive, easy-to-use software interface. What might have been impossible or have taken days can now be done in minutes.
CRi multispectral images and industry-standard TIFFs, including TIFFs generated by CRi's new Whole Slide Imaging systems, can be read and analyzed by inForm.
To see how inForm can help you, for a limited time send us your slides for a free analysis!
The software is based on machine-learning, which means that you can train the program to create an effective solution by simply drawing around examples of what you want segmented in your images. inForm then creates a solution that you can subsequently apply across the entire image or across as many images as you want. The output can be a wide range of parameters, such as numbers of objects, locations, and the spectrally unmixed signal levels. If the objects are cells, the output can be multi-parameter protein expression per cell, like that produced by modern flow cytometry, with the major advantage being that the morphological context and heterogeneity of the tissue sample are retained.
inForm segmented image and Nuance unmixed composite image from breast cancer specimen. inForm is compatible with CRi's Nuance multispectral imaging systems and utilizes sophisticated machine-learning algorithms to achieve its high performance and accuracy.
Sample courtesy BC Cancer Agency.
