DyCE™
Dynamic Contrast Enhancement (DyCE™) is a revolutionary new temporally based imaging solution for generating all-optical anatomic images of mice or for increasing sensitivity of injectable fluorescent reagents and labeled antibodies.
Licensed from Harvard, DyCE can provide anatomic maps of most of the major organs in a mouse in only a few minutes. By utilizing rapid data acquisition and sophisticated temporal analysis software methodologies, DyCE can provide high-quality color reference images. In addition, utilizing the same temporal data analysis methods, DyCE can provide quantitative data about uptake of markers at much earlier time points than is possible using simple imaging methods.
The DyCE package includes a C3 mirror accessory, which provides multiple views of an animal simultaneously, and the software for temporal DyCE data collection and analysis.
Click on images to enlarge
Figures: 1) Anatomic images such as this one showing color-coded internal organs can be generated in minutes using the all-optical technique of DyCE, 2) Time sequence of a DyCE acquisition. A data cube is created where each pixel contains wavelength and intensity data over time. Images courtesy E. Hillman, Columbia University.
Hillman, E.M.C. and A. Moore, All-optical anatomical co-registration for molecular imaging of small animals using dynamic contrast. Nat Photon, 2007. 1(9): p. 526-530.
