DyCE™
All-optical anatomic and kinetic imaging
Dynamic Contrast Enhancement (DyCE™) is a revolutionary new time-based imaging solution for generating all-optical anatomic images of mice and for increasing imaging sensitivity of injectable fluorescent reagents and labeled antibodies.
Exclusively licensed from Massachusetts General Hospital, DyCE can provide anatomic maps of most of the major organs in a mouse in only a few minutes. By utilizing rapid data acquisition and sophisticated temporal analysis software, DyCE provides high-quality color reference images. In addition, utilizing the same temporal data analysis methods, DyCE provides quantitative data on the temporal biodistribution of fluorescent markers at much earlier time points than is possible using conventional imaging methods, and can help better discriminate between bound and unbound antibodies. The DyCE package includes the MultiView accessory, which provides multiple views of an animal simultaneously, and additional software for temporal DyCE data collection and analysis.
Dynamic Contrast Enhancement (DyCE) enables an all-optical anatomic organ map to be constructed from a mouse using a time-series of Maestro spectral image datasets and sophisticated software algorithms. The technique also dramatically reduces the time to distinguish specific from non-specific binding by as much as 90%.
Images courtesy Elizabeth Hillman, Columbia University.
