In Vivo Imaging
In vivo imaging has become a critical component of drug development and medical practice. However, most whole animal imaging modalities reveal anatomical rather than molecular features. CRi's award-winning in-vivo molecular imaging Maestro systems incorporate breakthrough technology that provides quantitative spatial information about molecular markers such as proteins and RNA in whole small animals. CRi also has exclusive licensing rights to Dynamic Contrast Enhancement (DyCE™) which is used to create anatomical surface maps of major internal organs that can be readily co-registered with molecular imaging data obtained in the same animal. The Maestro system can also remove the confounding effects of skin and tissue autofluorescence, resulting in dramatic, hundred-fold increases in sensitivity of fluorescent labels.
Click on images to enlarge
Image 1: Tumors and vasculature labeled with Anti-CEA antibody. (Invitrogen Corporation)
Image 2: Triple labeled, co-expression of AF-markers. (Stanford Univ Workshop)
Image 3: QDot detection after unmixing food and tissue autofluorescence. (S Nie, Emory Univ)
