Fluorescence Microscopy
Fluorescence microscopy is a critical tool for academic and pharmaceutical research, pathology, and clinical medicine. However, there is an increased need for multiplexed fluorescent marker studies, as the complexity of disease becomes more apparent. Until now, there have been no practical, fast, or economical means to assess multiple protein and pathway configurations in tissue sections, on a cell-by-cell basis. CRi's Nuance system enables quantitative multiplexing of multiple fluorescent molecular markers in intact tissue sections at an affordable price and high-throughput format. CRi's Nuance system can also effectively eliminate the confounding effects of autofluorescence, revealing otherwise invisible molecular targets.
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Image 1: Four Alexa fluor dyes in mouse intestine. (Molecular Probes)
Image 2: Five QDots in lymph node germinal center. (S Pittaluga, NCI)
Image 3: Triple-labeled liver tissue. (L Komuves, Genentech)
